Effects of phosphate binder therapy on vascular stiffness in early-stage chronic kidney disease

ME Seifert, L De Las Fuentes, M Rothstein… - American journal of …, 2013 - karger.com
… of vascular stiffness), cIMT, or VC. This study does not lend support for further study of
phosphate binders in early-stage CKD because of the failure to affect phosphate homeostasis. A …

… and arterial stiffness burden in a chronic kidney disease cohort with high cardiovascular risk: baseline characteristics of the impact of phosphate reduction on vascular …

NM Lioufas, E Pedagogos, CM Hawley… - American journal of …, 2020 - karger.com
… the effect of the phosphate binder lanthanum carbonate on intermediate cardiovascular
It is upregulated from an early stage of CKD and is an important biomarker in CKD-MBD. …

A randomized trial on the effect of phosphate reduction on vascular end points in CKD (IMPROVE-CKD)

ND Toussaint, E Pedagogos, NM Lioufas… - Journal of the …, 2020 - journals.lww.com
kidney function, and … of effect of phosphate binders on cardiovascular intermediate markers
in our study was consistent with an open-labeled clinical trial, which randomized 120 patients

Con: Phosphate binders in chronic kidney disease

B Kestenbaum - Nephrology Dialysis Transplantation, 2016 - academic.oup.com
Phosphate binders are prescribed to chronic kidney disease (CKD) patients based on
associations of serum phosphate … Null effects of phosphate binders on these hormones may reflect …

Effects of phosphate binding with sevelamer carbonate on cardiovascular structure and function in patients with early chronic kidney disease

CD Chue - 2013 - etheses.bham.ac.uk
… oral, non-calcium-based phosphate binder, are assessed in a … trial of 120 patients with stage
3 chronic kidney disease. … the burden of cardiovascular disease caused by early stage CKD, …

… outcomes through phosphate lowering in CKD? Rationale and protocol for the IMpact of Phosphate Reduction On Vascular End-points in Chronic Kidney Disease  …

N Lioufas, ND Toussaint, E Pedagogos, G Elder… - BMJ open, 2019 - bmjopen.bmj.com
Effects of phosphate binder therapy on vascular stiffness in early-stage chronic kidney
disease… calcium-based phosphate binders in patients with chronic kidney disease: a systematic …

Pro: Should phosphate binders be used in chronic kidney disease stage 3–4?

A Bellasi - Nephrology Dialysis Transplantation, 2016 - academic.oup.com
… trials that have investigated the impact of phosphate binders in CKD patients. The aim of
the … view on the phosphate binder use in non-dialysis dependent CKD patients (NDD-CKD). …

Optimal use of phosphate binders in chronic kidney disease

M Sonikian, E Papachristou… - Expert opinion on …, 2013 - Taylor & Francis
… In conclusion, many studies showed that lanthanum carbonate has similar clinical adverse
effects with other phosphate binders, arising mostly from GI tract. Studies in humans did not …

Systematic review and meta-analyses of the effects of phosphate-lowering agents in nondialysis CKD

NM Lioufas, EM Pascoe, CM Hawley… - Journal of the …, 2022 - journals.lww.com
… those with cardiovascular disease, but normal kidney function, … effects on PWV between
the noncalcium phosphate binderphosphate binders also had uncertain effects on vascular

[HTML][HTML] Arterial stiffness, vascular calcification and bone metabolism in chronic kidney disease

J Nemcsik, I Kiss, A Tislér - World journal of nephrology, 2012 - ncbi.nlm.nih.gov
… The non-calcium-containing phosphate binder sevelamer has been linked to slowing the …
We demonstrated its beneficial effect for arterial stiffness parameters in dialysis patients